An active

AZ 5104 – 10 mg

Brand:
Cayman
CAS:
1421373-98-9
Storage:
-20
UN-No:
Non-Hazardous - /

AZ 5104 is an active, demethylated metabolite of AZD 9291 (Item No. 16237), an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC50s = 15-17 nM) that spares the wild-type form of the receptor (IC50 = 480 nM).{27820,32544,32545} AZ 5104 displays a similar overall activity profile as the parent compound.{32544,32545}  

 

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Description

An active, demethylated metabolite of AZD 9291

Formal name: N-[2-[[2-(dimethylamino)ethyl]methylamino]-5-[[4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-4-methoxyphenyl]-2-propenamide

Synonyms: 

Molecular weight: 485.6

CAS: 1421373-98-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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