An inhibitor of LDHA (Kd = 0.093 μM; IC50 = 0.5 μM); selective for LDHA over LDHB in an NADH competition assay using recombinant enzymes (IC50s = 0.54 and 3.6 μM

AZ 33 – 5 mg

Brand:
Cayman
CAS:
1370290-34-8
Storage:
-20
UN-No:
Non-Hazardous - /

AZ 33 is an inhibitor of lactate dehydrogenase A (LDHA; Kd = 0.093 μM; IC50 = 0.5 μM).{36785} It is selective for LDHA over LDHB in an NADH competition assay using recombinant enzymes (IC50s = 0.54 and 3.6 μM, respectively).{36786} AZ 33 is cell-impermeable and lacks cytotoxicity against HeLa cervical cancer cells (IC50 = >500 μM).  

 

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SKU: 25444 - 5 mg Category:

Description

An inhibitor of LDHA (Kd = 0.093 μM; IC50 = 0.5 μM); selective for LDHA over LDHB in an NADH competition assay using recombinant enzymes (IC50s = 0.54 and 3.6 μM, respectively); cell-impermeable and lacks cytotoxicity against HeLa cervical cancer cells (IC50 = >500 μM),

Formal name: 2-[[4-[4-[[3-[(2-methyl-6-benzothiazolyl)amino]-3-oxopropyl]amino]-4-oxobutyl]phenyl]methyl]-propanedioic acid

Synonyms: 

Molecular weight: 497.6

CAS: 1370290-34-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area

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