A selective Mps1 inhibitor (IC50 = 35 nM); inhibits the recruitment of Mad1

AZ 3146 – 5 mg

Brand:
Cayman
CAS:
1124329-14-1
Storage:
-20
UN-No:
Non-Hazardous - /

AZ 3146 is an inhibitor of the monopolar spindle 1 (Mps1) checkpoint kinase (IC50 = 35 nM).{33103} It displays selectivity over 46 other kinases including Cdk1 and Aurora kinase B.{33103} It has been shown to inhibit the recruitment of Mad1, Mad2, and centromere protein E (CENP-E) to kinetochores.{33103} AZ 3146 can be used with GSK923295 (Item No. 18389), an inhibitor of CENP-E, to generate aneuploidy in cells.{31964}  

 

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Description

A selective Mps1 inhibitor (IC50 = 35 nM); inhibits the recruitment of Mad1, Mad2, and CENP-E to kinetochores

Formal name: 9-cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one

Synonyms:  Mps1 Inhibitor III

Molecular weight: 452.6

CAS: 1124329-14-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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