CD3ε-Nck interaction; inhibits T cell receptor-triggered T cell activation (IC50 = 1 nM); prevents CD4+ T cell and macrophage infiltration to the cerebellum and spinal cord and improves neurological impairments in a MOG35-55 mouse model of EAE at 10 mg/kg per day; prevents the infiltration of eosinophils

AX-024 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
1704801-24-0
Storage:
-20
UN-No:
Non-Hazardous - /

AX-024 is an inhibitor of the CD3ε-Nck interaction.{49065} It binds to the SH3.1 N-terminal domain of Nck1, preventing its binding to the proline-rich sequence of the CD3ε subunit of T cells. AX-024 inhibits T cell receptor-triggered T cell activation (IC50 = 1 nM for human T cells) and selectively decreases proliferation of T cells over B cells. It prevents CD4+ T cell and macrophage infiltration to the cerebellum and spinal cord and improves neurological impairments in a MOG35-55 mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at a dose of 10 mg/kg per day for ten days starting on the day of immunization. AX-024 (50 mg/kg) prevents the infiltration of eosinophils, macrophages, and neutrophils into the airway, as well as prevents an increase in IL-4 levels in bronchoalveolar lavage fluid (BALF), in an ovalbumin-sensitized mouse model of allergic airway disease. It does not prevent the memory T cell response to an immunodominant B8R poxvirus antigen peptide or to infection by ectromelia virus (mousepox).  

 

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SKU: 27333 - 10 mg Category:

Description

CD3ε-Nck interaction; inhibits T cell receptor-triggered T cell activation (IC50 = 1 nM); prevents CD4+ T cell and macrophage infiltration to the cerebellum and spinal cord and improves neurological impairments in a MOG35-55 mouse model of EAE at 10 mg/kg per day; prevents the infiltration of eosinophils, macrophages, and neutrophils into the airway in an ovalbumin-sensitized mouse model of allergic airway disease at 50 mg/kg

Formal name: 1-[[4-(4-fluorophenyl)-6-methoxy-2H-1-benzopyran-3-yl]methyl]-pyrrolidine, monohydrochloride

Synonyms: 

Molecular weight: 375.9

CAS: 1704801-24-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience

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