A partial agonist of the GABAA receptor that acts at the benzodiazepine binding site

AWD 131-138 – 10 mg

Brand:
Cayman
CAS:
188116-07-6
Storage:
-20
UN-No:
Non-Hazardous - /

AWD 131-138 is a partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.0 µM.{29595} This effect is blocked by the benzodiazepine antagonist flumazenil (Item No. 14252).{29595} AWD 131-138 displays a broad spectrum of anticonvulsant activity in diverse seizure and epilepsy models without a tendency toward tolerance or abuse.{29593,29594,29596} It has a superior pharmacokinetic profile in dogs vs. humans.{29594,29592}  

 

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Description

A partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.0 µM; displays a broad spectrum of anticonvulsant activity in diverse seizure and epilepsy models without a tendency toward tolerance or abuse

Formal name: 1-(4-chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one

Synonyms:  ELB138|Imepitoin

Molecular weight: 279.7

CAS: 188116-07-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Seizure Disorders

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