A full-spectrum UVA blocker; inhibits UVA-induced melanin and tyrosinase activity in B16/F10 melanoma cells (IC30s = 21.94 and 24.25 μM

Avobenzone – 100 g

Brand:
Cayman
CAS:
70356-09-1
Storage:
-20
UN-No:
Limited Quantity - 3077 / 9

Avobenzone is a full-spectrum ultraviolet A (UVA) blocker.{41451} It inhibits UVA-induced melanin and tyrosinase activity in B16/F10 melanoma cells (IC30s = 21.94 and 24.25 μM, respectively).{41452} Avobenzone (30 μM) also inhibits UVA-induced production of reactive oxygen species (ROS) and 8-hydroxy-2′-deoxyguanosine (8-OH-dG; Item No. 89320) and depletion of glutathione (GSH; Item No. 10007461) in B16/F10 cells. It increases nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and upregulates the antioxidant response element (ARE) in UVA-irradiated B16/F10 cells at a concentration of 30 μM. Formulations containing avobenzone have been used as a sun protectant in sunscreen products.  

 

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SKU: 23836 - 100 g Category:

Description

A full-spectrum UVA blocker; inhibits UVA-induced melanin and tyrosinase activity in B16/F10 melanoma cells (IC30s = 21.94 and 24.25 μM, respectively); inhibits UVA-induced production of ROS and 8-OH-dG and depletion of GSH in B16/F10 cells (30 μM); increases nuclear translocation of Nrf2 and upregulates ARE in UVA-irradiated B16/F10 cells (30 μM)

Formal name: 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1,3-propanedione

Synonyms:  BMDBM|Butyl Methoxydibenzoylmethane

Molecular weight: 310.4

CAS: 70356-09-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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