A selective IMPDH inhibitor (Ki = 6-10 nM for both human IMPDH isoforms); inhibits the de novo synthesis of purines

AVN944 – 1 mg

Brand:
Cayman
CAS:
297730-17-7
Storage:
-20
UN-No:
Non-Hazardous - /

AVN944 is a selective, noncompetitive inhibitor of inosine-5′-monophosphate dehydrogenase (IMPDH; Ki = 6-10 nM for both human IMPDH isoforms), a rate-limiting enzyme involved in the de novo synthesis of purine nucleotides.{33492} Inhibition of IMPDH results in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 has been shown to inhibit the proliferation of multiple myeloma cells in vitro by inducing caspase-independent apoptosis.{33492} It is also reported to have antitumor properties in androgen-sensitive and androgen-independent prostate cancer cells in vitro.{33491}  

 

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Description

A selective IMPDH inhibitor (Ki = 6-10 nM for both human IMPDH isoforms); inhibits the de novo synthesis of purines, disrupts DNA and RNA synthesis, inhibits cell proliferation, and induces apoptosis

Formal name: N-[(1S)-1-[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]-carbamic acid, (1R)-1-(cyanomethyl)propyl ester

Synonyms: 

Molecular weight: 477.5

CAS: 297730-17-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death|Apoptosis

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