A β-lactamase inhibitor (IC50s = 8

Avibactam (sodium salt) – 5 mg

Brand:
Cayman
CAS:
1192491-61-4
Storage:
-20
UN-No:
Non-Hazardous - /

Avibactam is a β-lactamase inhibitor (IC50s = 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively).{39116,39113} It restores the antimicrobial activity of ceftazidime (Item No. 14828), ceftriaxone (Item No. 18866), imipenem (Item No. 16039), and piperacillin (Item No. 20766) against antibiotic-resistant Enterobacteriaceae in vitro (MIC90 reduction 4-1,024-fold across 190 E. coli and K. pneumoniae clinical isolates).{39114} Formulations containing avibactam have been used to treat carbapenem-resistant Enterobacteriaceae infections.{39115}  

 

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Description

A β-lactamase inhibitor (IC50s = 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively); restores antimicrobial activity of ceftazidime, ceftriaxone, imipenem and piperacillin in vitro (MIC90 reduction 4-1024-fold across 190 E. coli and K. pneumoniae clinical isolates), ,

Formal name: sulfuric acid, mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester, monosodium salt

Synonyms:  AVE-1330A|NXL104

Molecular weight: 287.2

CAS: 1192491-61-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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