An aglycone form of avermectin B1a; hyperpolarizes P. crassipes muscle fibers (MAC = 0.1 μM); decreases survival of C. elegans (MAC = 0.1 μM); prevents PTZ-induced seizures in mice (ED50 = 43.9 mg/kg)

Avermectin B1a aglycone – 5 mg

Brand:
Cayman
CAS:
71828-14-3
Storage:
-20
UN-No:
Non-Hazardous - /

Avermectin B1a aglycone is an aglycone form of the anthelmintic and insecticide avermectin B1a (Item No. 22000).{46109} It hyperpolarizes P. crassipes muscle fibers with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B1a aglycone decreases survival of C. elegans (MAC = 0.1 μM). In vivo, avermectin B1a aglycone prevents seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in mice (ED50 = 43.9 mg/kg) without inducing deficits in rotarod performance.{35146}  

 

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SKU: 28051 - 5 mg Category:

Description

An aglycone form of avermectin B1a; hyperpolarizes P. crassipes muscle fibers (MAC = 0.1 μM); decreases survival of C. elegans (MAC = 0.1 μM); prevents PTZ-induced seizures in mice (ED50 = 43.9 mg/kg)

Formal name: (6R,13S,25R)-22,23-didehydro-5-O-demethyl-28-deoxy-6,28-epoxy-13-hydroxy-25-[(1S)-1-methylpropyl]-milbemycin B

Synonyms: 

Molecular weight: 584.7

CAS: 71828-14-3

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Neuroscience|Seizure Disorders

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