An anthelmintic and insecticidal agent; binds to high and low affinity sites on the mammalian GABAA receptor to activate or block calcium influx

Avermectin B1a – 1 mg

Brand:
Cayman
CAS:
65195-55-3
Storage:
-20
UN-No:
De Minimis - 2588 / 6.1

Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent that binds to high and low affinity sites on the mammalian GABAA receptor.{35015,35017,35019} Binding to the high affinity site activates the receptor to increase chloride influx, while binding to the low affinity site blocks the channel.{35019} Avermectin B1a inhibits binding of the glycine receptor antagonist strychnine to membranes and the solubilized receptor from rat spinal cord (Kis = 1.3 and 3.6 µM, respectively).{35020} Formulations containing avermectin B1a (>80%) and avermectin B1b (~20%; Item No. 17453) are used in insecticides and veterinary anthelmintic formulas as abamectin (Item No. 19201).{35016,35018}  

 

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Description

An anthelmintic and insecticidal agent; binds to high and low affinity sites on the mammalian GABAA receptor to activate or block calcium influx, respectively; inhibits binding of strychnine to the glycine receptor (Kis = 1.3 and 3.6 µM, respectively),

Formal name: 5-O-demethyl-avermectin A1a

Synonyms:  ​Abamectin B1a|Antibiotic C 076B1a|L-676,863

Molecular weight: 873.1

CAS: 65195-55-3

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Neuroscience

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