A potent and selective PDE5 inhibitor (IC50s = 2.2

Avanafil – 500 mg

Brand:
Cayman
CAS:
330784-47-9
Storage:
-20
UN-No:
Non-Hazardous - /

Avanafil is an orally bioavailable, potent, and competitive inhibitor of phosphodiesterase (PDE) 5 (IC50 = 2.2 nM).{40239} It is selective, with IC50 values of 630, >5,000, and >5,000 nM for PDE6, PDE1-4, and PDE7-11, respectively, in an enzyme assay. Avanafil potentiates penile tumescence in dogs in a dose-dependent manner. Formulations containing avanafil have been used to treat erectile dysfunction.{40271}  

 

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SKU: 23024 - 500 mg Category:

Description

A potent and selective PDE5 inhibitor (IC50s = 2.2, 630, >5,000, and >5,000 nM for PDE5, PDE6, PDE1-4, and PDE7-11, respectively, in an enzyme assay); potentiates penile tumescence in dogs in a dose-dependent manner

Formal name: 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide

Synonyms:  TA-1790

Molecular weight: 484

CAS: 330784-47-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area

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