A positive modulator of Kv3.1b

AUT1 – 10 mg

Brand:
Cayman
CAS:
1311136-84-1
Storage:
-20
UN-No:
Non-Hazardous - /

AUT1 is a positive modulator of the voltage-gated potassium channel subtypes Kv3.1b, Kv3.2a, and Kv3.3 (EC50s = 4.7, 4.9, and 31.6 µM, respectively, in a patch-clamp assay).{46494} It is selective for Kv3.1b, Kv3.2a, and Kv3.3 over Kv1.5 and Kv7.1/minK channels but also inhibits the serotonin (5-HT) transporter, 5-HT3 receptor, and α1 subunit-containing nicotinic acetylcholine receptor (nAChR) in a panel of 26 ion channels, receptors, and transporters. AUT1 increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices when used at concentrations of 1 and 10 µM.  

 

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Description

A positive modulator of Kv3.1b, Kv3.2a, and Kv3.3 (EC50s = 4.7, 4.9, and 31.6 µM, respectively, in a patch-clamp assay); selective for Kv3.1b, Kv3.2a, and Kv3.3 over Kv1.5 and Kv7.1/minK channels but also inhibits the 5-HT transporter, 5-HT3 receptor, and α1 subunit-containing nAChR in a panel of 26 ion channels, receptors, and transporters; increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices at 1 and 10 µM

Formal name: 5R-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione

Synonyms: 

Molecular weight: 341.4

CAS: 1311136-84-1

Purity: ≥98%

Formulation: A crystalline solid

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