Description
A pyrrolizidine alkaloid; an inhibitor of glucoamylase (IC50 = 5.8 µM); that also inhibits glucosidase I, sucrase, maltase, and A. niger α-glucosidase (IC50s = 20, 28, 35, and 28 µM, respectively); selective for these enzymes over glucosidase II, α- and β-mannosidase, and α- and β-galactosidase up to 500 µM, β-glucosidase, with only 5% inhibition at 66 µM, as well as isomaltase and trehalase (IC50 = 97 and 160 µM, respectively); inhibits glycoprotein processing of viral glycoproteins in influenza virus-infected MDCK cells and induces the accumulation of glycoproteins at 500 µg/ml
Formal name: (1R,2R,3R,7S,7aR)-hexahydro-3-(hydroxymethyl)-1H-pyrrolizine-1,2,7-triol, monohydrochloride
Synonyms: (+)-Australine|7a-epi-Alexine
Molecular weight: 225.7
CAS: 186766-07-4
Purity: ≥95%
Formulation: A crystalline solid
