A cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC50 = 0.39 µM); blocks MCF-7 cells proliferation with an IC50 value of 1.25 µM

Aurora Kinase Inhibitor II – 5 mg

Brand:
Cayman
CAS:
331770-21-9
Storage:
-20
UN-No:
Non-Hazardous - /

The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC50 = 0.39 µM).{29266} In MCF-7 cells, it blocks proliferation with an IC50 value of 1.25 µM.{29266}  

 

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Description

A cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC50 = 0.39 µM); blocks MCF-7 cells proliferation with an IC50 value of 1.25 µM

Formal name: N-[4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenyl]-benzamide

Synonyms:  4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline

Molecular weight: 400.4

CAS: 331770-21-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Aurora||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Aurora Signaling

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