A natural pyrazinone produced by certain fungi and by Staphylococcus spp. that inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 µM)

Aureusimine B – 1 mg

Brand:
Cayman
CAS:
170713-71-0
Storage:
-20
UN-No:
Non-Hazardous - /

Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus.{31506,31173} Its synthesis appears to be initiated by a conserved nonribosomal peptide synthetase that creates a dipeptide (phenylalanine-valine) aldehyde, which then undergoes cyclization and oxidation.{31173} Aureusimine B inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 µM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression.{31506,31507,31508}  

 

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Description

A natural pyrazinone produced by certain fungi and by Staphylococcus spp. that inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 µM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression

Formal name: 3-(1-methylethyl)-6-(phenylmethyl)-2(1H)-pyrazinone

Synonyms:  Phevalin​

Molecular weight: 228.3

CAS: 170713-71-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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