A broad-spectrum dithiolopyrrolone antibiotic; inhibits tumor angiogenesis

Aureothricin – 500 µg

Brand:
Cayman
CAS:
574-95-8
Storage:
-20
UN-No:
Non-Hazardous - /

Aureothricin is a dithiolopyrrolone antibiotic first isolated from Streptomyces sp. that exhibits broad-spectrum antimicrobial activity against many Gram-positive and Gram-negative bacteria, as well as strains of M. tuberculosis.{31616} It is also reported to inhibit tumor angiogenesis, blocking activity of the vitronectin receptor integrin αvβ3 with an IC50 value of 1.1 µM.{31617}  

 

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Description

A broad-spectrum dithiolopyrrolone antibiotic; inhibits tumor angiogenesis, blocking activity of integrin αvβ3, (IC50 = 1.1 µM)

Formal name: N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-propanamide

Synonyms:  Farcinicin|Propionylpyrrothione

Molecular weight: 242.3

CAS: 574-95-8

Purity: ≥98%

Formulation: A powder

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Angiogenesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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