An anthraquinone with diverse biological activities; inhibits RLAR in vitro (IC50 = 13.6 μM); activates the AhR at 10 and 100 μM; inhibits arachidonic acid-

Aurantioobtusin – 10 mg

Brand:
Cayman
CAS:
67979-25-3
Storage:
-20
UN-No:
Non-Hazardous - /

Aurantioobtusin is an anthraquinone originally isolated from Cassia seeds with diverse biological activities.{47459,47460,47461,47462,47463} It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 13.6 μM).{47459} Aurantioobtusin (10 and 100 μM) activates the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner.{47460} It inhibits rat platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), ADP, and collagen.{47461} Aurantioobtusin induces vasorelaxation in isolated precontracted rat mesenteric artery rings, an effect that is inhibited by the PI3K inhibitor LY290042 or inhibition of endothelial nitric oxide synthase (eNOS).{47462} It is larvicidal against A. gambiae mosquitoes (LD50 = 10 ppm).{47463}  

 

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SKU: 27481 - 10 mg Category:

Description

An anthraquinone with diverse biological activities; inhibits RLAR in vitro (IC50 = 13.6 μM); activates the AhR at 10 and 100 μM; inhibits arachidonic acid-, ADP-, and collagen-induced rat platelet aggregation; induces vasorelaxation in isolated precontracted rat mesenteric artery rings; larvicidal against A. gambiae mosquitoes (LD50 = 10 ppm)

Formal name: 1,3,7-trihydroxy-2,8-dimethoxy-6-methyl-9,10-anthracenedione

Synonyms: 

Molecular weight: 330.3

CAS: 67979-25-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Anthraquinones||Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Toxicology|Drug Metabolism|Xenobiotic Sensing

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