An atrial natriuretic peptide; binds to ANP receptors on culture VSMCs (Kd = 1-2 nM) and increases cGMP dose-dependently; relaxes potassium-induced contraction of isolated canine renal arterial strips (10 and 100 ng/ml); dilates renal arteries in anesthetized dogs (10-100 ng/kg); decreases cardiomyocyte size and the amount of cardiac fibrosis and left ventricular modeling in a rat model of heart failure

Atrial Natriuretic Peptide (1-28) (human) (trifluoroacetate salt) – 1 mg

Brand:
Cayman
CAS:
89213-87-6
Storage:
-20
UN-No:
Non-Hazardous - /

Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart.{39427,39428} It has effects on the renal and cardiovascular systems that decrease vasoconstriction, inhibit renin secretion, and increase sodium excretion. Human ANP binds to ANP receptors on cultured vascular smooth muscle cells (VSMCs) with a Kd value of approximately 1-2 nM and increases cGMP levels in a dose-dependent manner.{38724} It relaxes potassium-induced contraction of isolated canine renal arterial strips when used at concentrations of 10 and 100 ng/ml and dilates renal arteries in anesthetized dogs when used at doses ranging from 10 to 100 ng/kg.{38725} In a rat model of heart failure following experimental autoimmune myocarditis, human ANP, via osmotic mini pump for 28 days, decreases cardiomyocyte size as well as the amount of cardiac fibrosis and left ventricular remodeling.{38726} ANP (1-28) (human) is a 28 amino acid peptide corresponding to the human protein sequence.  

 

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SKU: 24539 - 1 mg Category:

Description

An atrial natriuretic peptide; binds to ANP receptors on culture VSMCs (Kd = 1-2 nM) and increases cGMP dose-dependently; relaxes potassium-induced contraction of isolated canine renal arterial strips (10 and 100 ng/ml); dilates renal arteries in anesthetized dogs (10-100 ng/kg); decreases cardiomyocyte size and the amount of cardiac fibrosis and left ventricular modeling in a rat model of heart failure

Formal name: L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine, cyclic (7→23)-disulfide, trifluoroacetate salt

Synonyms:  ANF|ANP|Atrial Natriuretic Factor|α-Atriopeptin (human)

Molecular weight: 3,080.40

CAS: 89213-87-6

Purity: ≥95%

Formulation: A lyophilized powder

Product Type|Biochemicals|Peptides||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy||Research Area|Cardiovascular System|Kidney & Renal Disease

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