Description
A sesquiterpene with diverse biological activities; inhibits LPS-induced increases in TNF-α and NO production, as well as iNOS activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively); reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by FCA; reduces the number of microvessels in the air pouch wall by 58.27% at 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, PlGF, and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma; inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM); reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner; reverses stress-induced decreases in hippocampal levels of 5-HT and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner in a mouse model of depression induced by chronic unpredictable mild stress
Formal name: 4aS,5,6,7,8,8aS-hexahydro-3,8a-dimethyl-5-methylene-naphtho[2,3-b]furan-2(4H)-one
Synonyms: AO-I|ATL-1
Molecular weight: 230.3
CAS: 73069-13-3
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Behavioral Neuroscience|Depression
