An antiprotozoal agent; inhibits complex III activity on dihydroorotate in isolated P. falciparum and P. yoelii mitochondria more potently than in rat liver mitochondria (EC50s = 0.95

Atovaquone – 5 mg

Brand:
Cayman
CAS:
95233-18-4
Storage:
-20
UN-No:
Non-Hazardous - /

Atovaquone is a broad-spectrum antiprotozoal agent that is active against Plasmodium, Toxoplasma, and Babesia, among other protozoa.{39560} It inhibits complex III activity on dihydroorotate in isolated P. falciparum and P. yoelii mitochondria more potently than in rat liver mitochondria (EC50s = 0.95, 0.94, and 510 nM, respectively) and depolarizes the mitochondrial membrane in P. yoelii-infected mouse erythrocytes (EC50 = 260 nM).{39561,39562} Atovaquone also inhibits transport mediated by human breast cancer resistance protein (BCRP) and P-glycoprotein in membrane vesicles (IC50s = 0.23 and 6.8 μM, respectively).{39563} It inhibits the growth of T. gondii in MRC-5 human lung fibroblasts in vitro (IC50 = ~64 nM) and increases mean survival of T. gondii-infected mice from 5.5 to 21.2 days when administered at a dose of 100 mg/kg per day.{39564} Formulations containing atovaquone have been used in the treatment of Pneumocystis pneumonia and toxoplasmosis as well as in combination with proguanil in the treatment of malaria and babesiosis.  

 

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SKU: 23802 - 5 mg Category:

Description

An antiprotozoal agent; inhibits complex III activity on dihydroorotate in isolated P. falciparum and P. yoelii mitochondria more potently than in rat liver mitochondria (EC50s = 0.95, 0.94, and 510 nM, respectively); depolarizes the mitochondrial membrane in P. yoelii-infected mouse erythrocytes (EC50 = 260 nM); inhibits human BCRP- and P-glycoprotein-mediated transport in membrane vesicles (IC50s = 0.23 and 6.8 μM, respectively); inhibits the growth of T. gondii in MRC-5 human lung fibroblasts in vitro (IC50 = ~64 nM); increases mean survival of T. gondii-infected mice from 5.5 to 21.2 days (100 mg/kg per day)

Formal name: 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione

Synonyms:  BW 556C-80|BW 566C

Molecular weight: 366.8

CAS: 95233-18-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Pneumonia||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Infectious Disease|Parasitic Diseases|Toxoplasmosis

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