A prodrug and metabolite of atorvastatin

Atorvastatin lactone – 1 mg

Brand:
Cayman
CAS:
125995-03-1
Storage:
-20
UN-No:
Non-Hazardous - /

Atorvastatin lactone is a prodrug form of atorvastatin (Item No. 10493), an HMG-CoA reductase inhibitor used to lower blood cholesterol levels.{32968} The lactone hydrolyzes rapidly to the acid form of atorvastatin in human serum at room temperature.{32969} Atorvastatin lactone can also be formed in vivo from atorvastatin by certain uridine 5’-diphospho-glucuronosyltransferases.{32970} Like atorvastatin, the lactone inhibits P-glycoprotein in a concentration-dependent manner.{32967}  

 

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Description

A prodrug and metabolite of atorvastatin

Formal name: 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide

Synonyms: 

Molecular weight: 540.6

CAS: 125995-03-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Product Type|Biochemicals|Transporter & Exchanger Modulators||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Lipid Biochemistry|Sterol Lipids

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