A selective norepinephrine reuptake inhibitor (Kis = 5

Atomoxetine (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
82248-59-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki values of 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively.{38422} It is selective over the choline, GABA, and adenosine transporters, and a number of neurotransmitter receptors, ion channels, second messengers, and brain/gut peptides. In the rat prefrontal cortex (PFC), it increases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression. Atomoxetine (0.1, 0.5, and 1 mg/kg) reduces premature responding, a measure of impulsivity, by rats in the 5-choice serial reaction time test (5CSRTT) in a dose-dependent manner.{38421} It also has neuroprotective effects when administered prior to ischemic damage in a gerbil model of transient cerebral ischemia.{38423} Formulations containing atomoxetine have been used in the treatment of attention-deficit hyperactivity disorder (ADHD) in children, adolescents, and adults.  

 

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Description

A selective norepinephrine reuptake inhibitor (Kis = 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively); selective over other transporters, and a number of neurotransmitter receptors, ion channels, second messengers, and brain/gut peptides; increases extracellular norepinephrine and dopamine by 3-fold in the PFC; reduces premature responding by rats in the 5CSRTT when administered at doses of 0.1, 0.5, and 1 mg/kg; has neuroprotective effects in a gerbil model of transient cerebral ischemia

Formal name: N-methyl-γR-(2-methylphenoxy)-benzenepropanamine, monohydrochloride

Synonyms:  LY139603

Molecular weight: 291.8

CAS: 82248-59-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Neuroprotection|Ischemia

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