An inhibitor of SOD1 in human and mouse blood cells in vitro (IC50s = 2.91 and 3.51 μM

ATN-224 – 10 mg

Brand:
Cayman
CAS:
649749-10-0
Storage:
-20
UN-No:
Non-Hazardous - /

ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC50s = 2.91 and 3.51 µM in human and mouse blood cells, respectively, in vitro).{36253} ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC50s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC50s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL.{36254,36255} In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice.{36256} It also inhibits angiogenesis in a mouse model (IC50s = 1.50-3 mg/kg via gavage).{36253}  

 

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SKU: 23553 - 10 mg Category:

Description

An inhibitor of SOD1 in human and mouse blood cells in vitro (IC50s = 2.91 and 3.51 μM, respectively); reduces viability of human and mouse lymphoma cells in vitro independently of Bcl-2 and Bcl-xL (EC50s = 5-6 and 9.73-105.61 nM, respectively); chelates copper and stabilizes an antitumor viral vector in mice when used at a dose of 0.7 mg/kg; inhibits angiogenesis in a mouse model (IC50s = 1.5-3 mg/kg via gavage)

Formal name: 2-hydroxy-N,N,N-trimethyl-ethanaminium, tetrathioxomolybdate

Synonyms:  ​Bis-Choline Tetrathiomolybdate

Molecular weight: 432.5

CAS: 649749-10-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Metal Chelators||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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