A potent

Atglistatin – 5 mg

Brand:
Cayman
CAS:
1469924-27-3
Storage:
-20
UN-No:
Non-Hazardous - /

Adipose triglyceride lipase (ATGL or PNPLA2) catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets, generating diacylglyerol.{21269,21272} Atglistatin is a potent, selective, and competitive inhibitor of ATGL (IC50 = 0.7 μM).{24582} It does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases.{24582} Atglistatin blocks lipolysis by ATGL in vitro, in white adipose tissue organ cultures, and in vivo.{24582} It does not affect lipolysis in ATGL knockout mice.{24582}  

 

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Description

A potent, selective, and competitive inhibitor of ATGL (IC50 = 0.7 μM); does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases; blocks lipolysis by ATGL in vitro, in white adipose tissue organ cultures, and in vivo

Formal name: N’-[4’-(dimethylamino)[1,1’-biphenyl]-3-yl]-N,N-dimethyl-urea

Synonyms: 

Molecular weight: 283.4

CAS: 1469924-27-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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