Immunogen: Full-length human recombinant ATG5 protein • Host: Mouse • Species Reactivity: (+) Human; other species not tested • Cross Reactivity: (-) ATG8 • Applications: ELISA

ATG5 Monoclonal Antibody (Clone 4D5) – 100 µg

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Cayman
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Autophagy-related 5 (ATG5), formerly known as apoptosis-specific protein (ASP), is a protein that is essential to autophagosome elongation.{47096,47097,47098} ATG5 is covalently conjugated to the C-terminal glycine residue of ATG12 (ATG12-ATG5) and forms a non-covalent complex with ATG16 (ATG12-ATG5-ATG16), which functions as an E3 ubiquitin ligase-like enzyme to facilitate LC3 transfer from ATG3 to phosphatidylethanolamine in canonical autophagy. ATG12-ATG5 also binds to the ATG12-ATG5-interaction region of the lysosomally localized protein TECPR1, freeing the TECPR1 pleckstrin homology domain to interact with phosphatidylinositol 3-phosphate components in the autophagosome membrane, promoting autophagosome-lysosome fusion.{47098} Polymorphisms in ATG5 have been associated with various autoimmune diseases, including lupus nephritis and Behçet’s disease, gastrointestinal and colorectal cancers, as well as sporadic Parkinson’s disease and childhood asthma. Cayman’s ATG5 Monoclonal Antibody (Clone 4D5) can be used for ELISA, immunohistochemistry, and Western blot applications. The antibody recognizes the ATG5-ATG12 complex at approximately 56 kDa from human samples.  

 

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SKU: 26671 - 100 µg Category:

Description

Immunogen: Full-length human recombinant ATG5 protein • Host: Mouse • Species Reactivity: (+) Human; other species not tested • Cross Reactivity: (-) ATG8 • Applications: ELISA, IHC, and WB • MW: ~56 kDa for the ATG5-ATG12 complex

Synonyms: APG5-like|Apoptosis-specific Protein|Autophagy Protein 5|Autophagy-related 5|hAPG5

Immunogen: Full-length human recombinant ATG5 protein

Formulation: 100 µg of Protein G-purified monoclonal antibody

Isotype: IgG1

Applications: ELISA, IHC, and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer|Autophagy||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Immunology & Inflammation|Autoimmunity|Lupus||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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