An H2S-releasing NSAID; 30 µmol/kg in rats suppressed COX and gastric PGE2 synthesis to the same level as naproxen; accelerated rat spinal cord injury recovery; does not induce gastrointestinal toxicity; shows promising results in melanoma and intestinal tumorigenesis animal models

ATB-346 – 10 mg

Brand:
Cayman
CAS:
1226895-20-0
Storage:
-20
UN-No:
Non-Hazardous - /

ATB-346 is a non-steroidal anti-inflammatory drug (NSAID), derived from naproxen but coupled to an H2S-releasing moiety.{34012} At 30 µmol/kg in rats, it suppressed COX and gastric PGE2 synthesis to the same level as naproxen but reduced COX-2 expression and accelerated recovery in a rat spinal cord injury model.{34009} It also provided enhanced anti-inflammatory and antinociceptive activity over naproxen in a rat model of arthritis.{34011} ATB-346 does not induce gastrointestinal toxicity and, in contrast to other NSAIDs, it accelerated healing of pre-existing gastric ulcers.{34014} Studies of ATB-346 have shown promising results in vitro and in animal models of melanoma and intestinal tumorigenesis.{34010,34013} A Phase I clinical trial in Canada did not find any significant gastrointestinal, cardiovascular, renal, or hematological findings across dose ranges in healthy adults (25 mg–2,000 mg once/d).{34015} A Phase II trial in Canada is ongoing for patients with osteoarthritis of the knee.  

 

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Description

An H2S-releasing NSAID; 30 µmol/kg in rats suppressed COX and gastric PGE2 synthesis to the same level as naproxen; accelerated rat spinal cord injury recovery; does not induce gastrointestinal toxicity; shows promising results in melanoma and intestinal tumorigenesis animal models

Formal name: 6-methoxy-α-methyl-2-naphthaleneacetic acid, 4-(aminothioxomethyl)phenyl ester

Synonyms: 

Molecular weight: 365.5

CAS: 1226895-20-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Hydrogen Sulfide Donors||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Gastric Disease|Peptic Ulcers||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|H2S

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