Description
A flavonoid with diverse biological activities; inhibits cisplatin-induced increases in apoptosis and ROS in HEK293 cells at 200 μM; increases renal GSH levels and SOD and catalase activity and reduces serum creatinine and BUN levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity at 50 mg/kg; reduces loss of dopaminergic neurons in the substantia nigra and increases striatal GSH levels and SOD activity in a mouse model of MPTP-induced Parkinson’s disease at 50 mg/kg per day; reduces motor deficits in a mouse model of Parkinson’s disease; reduces cell viability of MDA-MB-231 and MCF-7 cells (IC50s = 167.9 and 191.6 μM, respectively), as well as inhibits migration and increases apoptosis at 50 and 200 μM; reduces tumor growth in an MCF-7 mouse xenograft model at 20 mg/kg every other day for 14 days
Formal name: (2R,3R)-3-[(6-deoxy-α-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one
Synonyms: Taxifolin 3-O-rhamnoside
Molecular weight: 450.4
CAS: 29838-67-3
Purity: ≥98%
Formulation: A crystalline solid
