A fungal metabolite; scavenges DPPH radicals in a cell-free assay (IC50 = 11.6 µM); inhibits GOT1 (Kd = 3.32 µM) and is cytotoxic to PANC-1

Aspulvinone O – 1 mg

Brand:
Cayman
CAS:
914071-54-8
Storage:
-20
UN-No:
Non-Hazardous - /

Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.{46739,46740} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 11.6 µM).{46739} Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 µM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 µM).{46740} It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) reduces tumor growth in an SW1990 mouse xenograft model.  

 

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SKU: 29959 - 1 mg Category:

Description

A fungal metabolite; scavenges DPPH radicals in a cell-free assay (IC50 = 11.6 µM); inhibits GOT1 (Kd = 3.32 µM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 µM); reduces the OCR and induces apoptosis in SW1990 cells; reduces tumor growth in an SW1990 mouse xenograft model at 2.5 and 5 mg/kg

Formal name: 3-[2,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-4-hydroxy-5-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methylene]-2(5H)-furanone

Synonyms: 

Molecular weight: 448.5

CAS: 914071-54-8

Purity: ≥95%

Formulation: A solid

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