Description
Asprosin is a glucogenic protein hormone secreted by white adipose tissue in mammals.{31498} This ~16 kDa protein is a 140 amino acid C-terminal cleavage product produced by furin cleavage of profibrillin. Asprosin increases glucose release via cyclic AMP (cAMP) and protein kinase A (PKA) in hepatocytes via interaction with a cell surface receptor, an effect that can be reversed by suramin, an inhibitor of heterotrimeric G proteins, or Rp-cAMPS (Item No. 16985), an antagonist of cAMP binding to PKA. In vivo, elevated plasma asprosin increases hepatic glucose production but does not affect glucose uptake in peripheral organs in response to insulin. Asprosin is orexigenic, activating AgRP+ neurons in a cAMP-dependent manner which leads to appetite stimulation and increased body weight.{37364} Plasma asprosin is elevated in adult humans and mice with type 2 diabetes mellitus and other genetic conditions that confer insulin resistance.{31498},{37365} Cayman’s Asprosin Polyclonal Antibody can be used for Western blot and immunoprecipitation.
Synonyms: Cleaved FBN1|Cleaved Fibrillin-1
Immunogen: Human recombinant protein
Formulation: 300 µg of protein A-purified IgG
Isotype:
Applications: IP and WB
Origin:
Stability: 730 days
Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity
