An iridoid glycoside with diverse biological activities; reduces microvessel formation by 67% in a chick embryo chorioallantoic membrane assay at 2 μg/egg; inhibits LPS-induced increases in TNF-α

Asperuloside – 1 mg

Brand:
Cayman
CAS:
14259-45-1
Storage:
-20
UN-No:
Non-Hazardous - /

Asperuloside is an iridoid glycoside that has been found in G. tunetanum and has diverse biological activities, including anti-angiogenic, anti-inflammatory, and anti-obesity properties.{48785,48786,48787} It reduces microvessel formation by 67% in a chick embryo chorioallantoic membrane assay when used at a concentration of 2 μg/egg.{48785} Asperuloside (20, 40, and 80 mg/L) inhibits LPS-induced increases in TNF-α, IL-1β, and IL-6 production in RAW 264.7 macrophages in a concentration-dependent manner.{48786} It reduces lung myeloperoxidase (MPO) activity and bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced acute lung injury when administered at doses of 20, 40, and 80 mg/kg. Dietary administration of asperuloside decreases body weight gain, white adipose tissue (WAT) weight, and the ratio of WAT weight to body weight in a high-fat diet-induced mouse model of metabolic syndrome.{48787}  

 

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Description

An iridoid glycoside with diverse biological activities; reduces microvessel formation by 67% in a chick embryo chorioallantoic membrane assay at 2 μg/egg; inhibits LPS-induced increases in TNF-α, IL-1β, and IL-6 production in RAW 264.7 macrophages in a concentration-dependent manner at 20, 40, and 80 mg/L; reduces lung MPO activity and BALF levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced acute lung injury at 20, 40, and 80 mg/kg; dietary administration decreases body weight gain, WAT weight, and the ratio of WAT weight to body weight in a high-fat diet-induced mouse model of metabolic syndrome

Formal name: 4-[(acetyloxy)methyl]-5-(β-D-glucopyranosyloxy)-2aS,4aS,5S,7bS-tetrahydro-1H-2,6-dioxacyclopent[cd]inden-1-one

Synonyms: 

Molecular weight: 414.4

CAS: 14259-45-1

Purity: ≥98%

Formulation: A solid

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