An amide originally isolated from P. aurantiacum that has diverse biological activities

Asperglaucide – 500 µg

Brand:
Cayman
CAS:
56121-42-7
Storage:
-20
UN-No:
Non-Hazardous - /

Asperglaucide is an amide originally isolated from P. aurantiacum that has diverse biological activities, including anti-inflammatory, antibacterial, antioxidant, and anticancer properties.{47611,47612,47613,47614} Asperglaucide inhibits production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), and IL-1β in LPS-stimulated BV-2 microglial cells (IC50s = 49.7, 51.5, and 40.4 µM, respectively).{47612} It is active against Gram-negative bacteria (MICs = 0.05-0.10 mg/ml) and has antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and Trolox equivalent antioxidant capacity (TEAC) assays (EC50s = 9.51-78.81 µg/ml).{47613} Asperglaucide decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 µM and reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model.{47614}  

 

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Description

An amide originally isolated from P. aurantiacum that has diverse biological activities, including anti-inflammatory, antibacterial, antioxidant, and anticancer properties; inhibits production of NO, PGE2, and IL-1β in LPS-stimulated BV-2 microglial cells (IC50s = 49.7, 51.5, and 40.4 µM, respectively); active against Gram-negative bacteria (MICs = 0.05-0.10 mg/ml); has antioxidant activity in DPPH and TEAC assays (EC50s = 9.51-78.81 µg/ml); decreases viability of U87 and U251 cancer cell in vitro when used at 10 to 100 µM; reduces tumor growth at 1 mg via intratumoral injection in a U87 mouse xenograft model

Formal name: N-[(1S)-1-[(acetyloxy)methyl]-2-phenylethyl]-αS-(benzoylamino)-benzenepropanamide

Synonyms:  Aurantiamide Acetate

Molecular weight: 444.5

CAS: 56121-42-7

Purity: ≥70%

Formulation: A solid

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