A fungal metabolite; induces morphological deformation of P. oryzae conidia at 89 nM; is active against S. epidermidis (MIC = 20 μM) but not S. aureus

Aspergillin PZ – 5 mg

Brand:
Cayman
CAS:
483305-08-4
Storage:
-20
UN-No:
- /

Aspergillin PZ is a fungal metabolite originally isolated from A. awamori.{43853} It induces morphological deformation of P. oryzae conidia when used at a concentration of 89 nM. Aspergillin PZ is active against S. epidermidis (MIC = 20 μM) but not S. aureus, E. coli, or B. cereus (MICs = >20 μM).{43854} It is cytotoxic to HL-60 promyelocytic leukemia cells (IC50 = 56.61 μM) but not THP-1 acute monocytic leukemia or PC3 prostate cancer cells (IC50s = >80 μM).{43855}  

 

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SKU: 27722 - 5 mg Category:

Description

A fungal metabolite; induces morphological deformation of P. oryzae conidia at 89 nM; is active against S. epidermidis (MIC = 20 μM) but not S. aureus, E. coli, or B. cereus (MICs = >20 μM); is cytotoxic to HL-60 promyelocytic leukemia cells (IC50 = 56.61 μM) but not THP-1 acute monocytic leukemia or PC3 prostate cancer cells (IC50s = >80 μM)

Formal name: (1R,2S,5R,5aS,5bS,8R,8aS,9R,11aR,13aR)-2,3,4,5,5a,5b,8,8a,9,10,13,13a-dodecahydro-2-hydroxy-5,7,8-trimethyl-9-(2-methylpropyl)-1,5-epoxy-1H-cyclohepta[3,4]benz[1,2-d]isoindole-11,12-dione

Synonyms: 

Molecular weight: 401.5

CAS: 483305-08-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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