A natural triterpene which stimulates wound healing; induces cell cycle arrest and apoptosis in breast cancer cells (IC50 = 5.9 µM for MCF-7 cells); blocks angiogenesis in glioblastomas; down regulates BACE1 while increasing ADAM10 maturation in primary rat cortical neurons; protects against neuronal damage and cognitive defects resulting from glutamate administration in vivo in mice

Asiatic Acid – 500 mg

Brand:
Cayman
CAS:
464-92-6
Storage:
-20
UN-No:
Non-Hazardous - /

Asiatic acid is a pentacyclic triterpene isolated from a variety of plants, including C. asiatica, used in traditional medicines. In addition to anti-inflammatory actions, asiatic acid stimulates wound healing by increasing collagen production.{22102} It has also been found to induce cell cycle arrest and apoptosis in breast cancer cells (IC50 = 5.9 µM for MCF-7 cells) and block angiogenesis in cells and tumors from glioblastomas.{22275,22276} Asiatic acid also impacts amyloid-β precursor protein processing by down regulating BACE1 while increasing ADAM10 maturation in primary rat cortical neurons.{22277} In addition, it reduces neuronal damage and cognitive defects resulting from glutamate administration in vivo in mice while demonstrating protective effects against glutamate-induced apoptosis in isolated SH-SY5Y cells.{22274}  

 

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SKU: 11818 - 500 mg Category:

Description

A natural triterpene which stimulates wound healing; induces cell cycle arrest and apoptosis in breast cancer cells (IC50 = 5.9 µM for MCF-7 cells); blocks angiogenesis in glioblastomas; down regulates BACE1 while increasing ADAM10 maturation in primary rat cortical neurons; protects against neuronal damage and cognitive defects resulting from glutamate administration in vivo in mice

Formal name: (4α)-2α,3β,23-trihydroxy-urs-12-en-28-oic acid

Synonyms:  Dammarolic Acid|NSC 166063

Molecular weight: 488.7

CAS: 464-92-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neuroprotection

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