A dual inhibitor of Cdk8 and Cdk19 (IC50s = 0.6 and 4.3 nM

AS-2863619 – 5 mg

Brand:
Cayman
CAS:
2241300-51-4
Storage:
-20
UN-No:
Non-Hazardous - /

AS-2863619 is a dual inhibitor of cyclin-dependent kinase 8 (Cdk8) and Cdk19 (IC50s = 0.6 and 4.3 nM, respectively).{58029} It induces Foxp3 expression in isolated mouse naïve T cells when used at a concentration of 1 µM alone or synergistically in combination with TGF-β. AS-2863619 (30 mg/kg) decreases ear edema and induces production of Foxp3+ regulatory T cells (Tregs) in mice. It also reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).  

 

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SKU: 30976 - 5 mg Category:

Description

A dual inhibitor of Cdk8 and Cdk19 (IC50s = 0.6 and 4.3 nM, respectively); induces Foxp3 expression in isolated mouse naïve T cells at 1 µM alone or synergistically with TGF-β; decreases ear edema and induces production of Foxp3+ Tregs in mice at 30 mg/kg; reduces disease severity in a mouse model of EAE

Formal name: 4-[1-(2-methyl-1H-benzimidazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine, dihydrochloride

Synonyms: 

Molecular weight: 405.2

CAS: 2241300-51-4

Purity: ≥98%

Formulation: A solid

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