An inhibitor of fungal complex III (IC50 = 80 ng/ml for T. mentagrophytes complex III); selective for fungal over mammalian complex III (IC50s = 480 and 860 ng/ml for murine EL-4 cell and human Jurkat cell complex III

AS-2077715 – 1 mg

Brand:
Cayman
CAS:
1637356-98-9
Storage:
-20
UN-No:
- /

AS-2077715 is a fungal metabolite and an inhibitor of fungal mitochondrial complex III (cytochrome bc1; IC50 = 80 ng/ml for T. mentagrophytes complex III).{52421} It is selective for fungal over mammalian complex III (IC50s = 480 and 860 ng/ml for murine EL-4 cell and human Jurkat cell complex III, respectively). AS-2077715 inhibits ATP production in (IC50 = 0.33 µg/ml) and is fungicidal against T. mentagrophytes when used at concentrations of 1 and 10 µg/ml. In vivo, AS-2077715 (10 and 20 mg/kg) reduces the number of foot pad skin colony forming units (CFUs) in a guinea pig model of T. mentagrophytes infection.{52422}  

 

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SKU: 29775 - 1 mg Category:

Description

An inhibitor of fungal complex III (IC50 = 80 ng/ml for T. mentagrophytes complex III); selective for fungal over mammalian complex III (IC50s = 480 and 860 ng/ml for murine EL-4 cell and human Jurkat cell complex III, respectively); inhibits ATP production in (IC50 = 0.33 µg/ml) and is fungicidal against T. mentagrophytes at 1 and 10 µg/ml; reduces the number of foot pad skin CFUs in a guinea pig model of T. mentagrophytes infection at 10 and 20 mg/kg

Formal name: 3-[6-(3,5-dimethylheptyl)tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-methyl-5-(2,3,4,5-tetrahydroxycyclopentyl)-2(1H)-pyridinone

Synonyms: 

Molecular weight: 467.6

CAS: 1637356-98-9

Purity: ≥70%

Formulation: A solid

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