A potent FoxO1 inhibitor (IC50 = 33 nM in HepG2 cells); causes a dose-dependent decrease in expression of G6Pase and PEPCK mRNAs and inhibits glucogenesis in Fao cells and a murine model of T2DM; inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes

AS-1842856 – 5 mg

Brand:
Cayman
CAS:
836620-48-5
Storage:
-20
UN-No:
Non-Hazardous - /

AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1; IC50 = 33 nM in HepG2 cells).{37141} Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and inhibits glucogenesis in rat hepatoma Fao cells and a murine model of type 2 diabetes mellitus (T2DM). AS-1842856 also inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes.{37142},{37143}  

 

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Description

A potent FoxO1 inhibitor (IC50 = 33 nM in HepG2 cells); causes a dose-dependent decrease in expression of G6Pase and PEPCK mRNAs and inhibits glucogenesis in Fao cells and a murine model of T2DM; inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes

Formal name: 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Synonyms:  FOXO1 Inhibitor

Molecular weight: 347.4

CAS: 836620-48-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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