A single enantiomer of a potent and selective inactivator of KIAA1363

(-)-AS 115 – 500 µg

Brand:
Cayman
CAS:
926657-43-4
Storage:
-20
UN-No:
De Minimis - 1231 / 3

KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues.{17107} The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network.{14603} AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SKOV3.{14603} Treatment of SKOV3 cells with 10 µM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e. (+)-AS 115 and (−)-AS 115, has not been determined.  

 

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Description

A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in addressive cancers from various tissues (IC50 = 150 nM when tested as a racemic mixture in SK0V-3 cells); activity of the individual enantiomers of AS 115, i.e. (+)-AS 115 and (−)-AS 115, has not been determined

Formal name: 2-fluorophenyl-(2-(((1R,2S)-2-(butoxymethyl)cyclohexyl)methoxy)ethyl)carbamate

Synonyms: 

Molecular weight: 381.5

CAS: 926657-43-4

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Small Molecule Inhibitors|Glycerolipid Lipases||Research Area|Cancer

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