An immunomodulator; inhibits IL-10 secretion from and cell proliferation of IL-10-secreting human stomach adenocarcinoma and GBM cells at 0.5-2.5 µg/ml; sensitizes GBM cells to paclitaxel

AS-101 – 10 mg

Brand:
Cayman
CAS:
106566-58-9
Storage:
-20
UN-No:
Non-Hazardous - /

AS-101 is an immunomodulator.{36943} It inhibits IL-10 secretion from and cell proliferation of IL-10-secreting human stomach adenocarcinoma and glioblastoma multiforme (GBM) cells when used at concentrations ranging from 0.5 to 2.5 µg/ml, an effect that can be blocked by the addition of recombinant IL-10. It reverses IL-10-induced increases in phosphorylated Stat3 and reduces the expression of Bcl-2 in B16 murine melanoma cells. AS-101 sensitizes GBM cells to paclitaxel (Item No. 10461), doxorubicin (Item No. 15007), and 5-fluorouracil (5-FU; Item No. 14416) in vitro and to paclitaxel in a GBM mouse xenograft model when administered at a dose of 0.5 mg/kg per day. AS-101 (1 mg/kg) also prevents infiltration of CD49d+ cells and decreases the expression of IL-6, TNF-α, IL-1β, and MCP-1 in the spinal cord, as well as delays onset and slows the progression of symptoms in a mouse model of experimental autoimmune encephalomyelitis (EAE).{36944}  

 

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Description

An immunomodulator; inhibits IL-10 secretion from and cell proliferation of IL-10-secreting human stomach adenocarcinoma and GBM cells at 0.5-2.5 µg/ml; sensitizes GBM cells to paclitaxel, doxorubicin, and 5-FU in vitro; sensitizes GBM cells to paclitaxel in a GBM mouse xenograft model at 0.5 mg/kg per day; prevents infiltration of CD49d+ cells and decreases the expression of IL-6, TNF-α, IL-1β, and MCP-1 in the spinal cord in a mouse model of EAE; delays onset and slows the progression of symptoms in a mouse model of EAE

Formal name: (SP-5-22)-trichloro[1,2-ethanediolato(2-)-κO1,κO2]-tellurate(1-), monoammonium salt

Synonyms: 

Molecular weight: 312

CAS: 106566-58-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Neuroscience

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