An inhibitor of astrocyte activation; reduces increases in brain GFAP and S100β levels in a rat model of permanent focal ischemia induced by middle cerebral artery occlusion at 10 mg/kg; decreases the number of TUNEL-positive neurons

Arundic Acid – 5 mg

Brand:
Cayman
CAS:
185517-21-9
Storage:
-20
UN-No:
Non-Hazardous - /

Arundic acid is an inhibitor of astrocyte activation.{53333} It reduces increases in brain glial fibrillary acid protein (GFAP) and S100β levels, markers of astrocyte activation, in a rat model of permanent focal ischemia induced by middle cerebral artery occlusion when administered at a dose of 10 mg/kg. Arundic acid (3 and 10 mg/kg) decreases the number of TUNEL-positive neurons, reduces infarct size, and improves motor performance in the rotarod test in the same model. It also reduces descent time and time to turn in a pole test, indicating reversal of motor deficits, in a mouse model of MPTP-induced Parkinson’s disease when administered at a dose of 30 mg/kg.{53334}  

 

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Description

An inhibitor of astrocyte activation; reduces increases in brain GFAP and S100β levels in a rat model of permanent focal ischemia induced by middle cerebral artery occlusion at 10 mg/kg; decreases the number of TUNEL-positive neurons, reduces infarct size, and improves motor performance in the rotarod test in the same model at 3 and 10 mg/kg; also reduces descent time and time to turn in a pole test in a mouse model of MPTP-induced Parkinson’s disease at 30 mg/kg

Formal name: 2R-propyl-octanoic acid

Synonyms:  ONO-2506

Molecular weight: 186.3

CAS: 185517-21-9

Purity: ≥95%

Formulation: A neat oil

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