An anti-malarial compound; active against P. falciparum in vitro (IC50 = 1.28 nM); an iron(II) oxide-reactive endoperoxide that generates ROS; inhibits proliferation of germinal center B cells in vitro; prevents development of arthritis via inhibition of germinal center formation and autoantibody production in the K/BxN mouse model of rheumatoid arthritis; inhibits bleomycin-induced alveolitis and pulmonary fibrosis in rats

Artesunate – 1 g

Brand:
Cayman
CAS:
88495-63-0
Storage:
-20
UN-No:
Non-Hazardous - /

Artesunate is a derivative of artemisinin (Item No. 11816) that is active against P. falciparum in vitro (IC50 = 1.28 nM).{21232} It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge.{35319} Artesunate inhibits proliferation of germinal center B cells in vitro and prevents development of arthritis via inhibition of germinal center formation and autoantibody production in the K/BxN mouse model of rheumatoid arthritis.{42468} It also inhibits alveolitis and pulmonary fibrosis induced by bleomycin (Item No. 13877) in rats.{42469}  

 

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SKU: 11817 - 1 g Category:

Description

An anti-malarial compound; active against P. falciparum in vitro (IC50 = 1.28 nM); an iron(II) oxide-reactive endoperoxide that generates ROS; inhibits proliferation of germinal center B cells in vitro; prevents development of arthritis via inhibition of germinal center formation and autoantibody production in the K/BxN mouse model of rheumatoid arthritis; inhibits bleomycin-induced alveolitis and pulmonary fibrosis in rats ,

Formal name: butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester

Synonyms:  Artesunic Acid|NSC 712571|WR 256283

Molecular weight: 384.4

CAS: 88495-63-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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