A sesquiterpene; decreases triglyceride levels and GPDH activity in hAMSCs; inhibits adipocyte differentiation at 200 µM; decreases C/EBPα and HMG-CoA reductase mRNA expression and inhibits cholesterol synthesis and melanogenesis in human epidermal melanocytes

Artemisinic Acid – 10 mg

Brand:
Cayman
CAS:
80286-58-4
Storage:
-20
UN-No:
Non-Hazardous - /

Artemisinic acid is a sesquiterpene that has been isolated from A. annua.{41903} It has been used in the synthesis of the antimalarial agent artemisinin (Item No. 11816).{41904} Artemisinic acid (50-400 µM) decreases triglyceride levels and glycerol-3-phosphate dehydrogenase (GPDH) activity in human adipose tissue-derived mesenchymal stem cells (hAMSCs) in a dose-dependent manner and inhibits adipocyte differentiation when used at a concentration of 200 µM.{41905} It reduces mRNA expression and protein levels of C/EBPα, C/EBPδ, and PPARγ as well as the ratio of phosphorylated JNK to JNK in hAMSCs. Artemisinic acid also decreases C/EBPα and HMG-CoA reductase mRNA expression and inhibits cholesterol synthesis and melanogenesis in human epidermal melanocytes.{41906}  

 

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SKU: 25059 - 10 mg Category:

Description

A sesquiterpene; decreases triglyceride levels and GPDH activity in hAMSCs; inhibits adipocyte differentiation at 200 µM; decreases C/EBPα and HMG-CoA reductase mRNA expression and inhibits cholesterol synthesis and melanogenesis in human epidermal melanocytes

Formal name: 1R,2,3,4R,4aS,5,6,8aR-octahydro-4,7-dimethyl-α-methylene-1-naphthaleneacetic acid

Synonyms:  Artemisic Acid

Molecular weight: 234.3

CAS: 80286-58-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Lipid Biochemistry|Glycerolipids||Research Area|Lipid Biochemistry|Glycerophospholipids||Research Area|Lipid Biochemistry|Sterol Lipids

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