An antiparasitic compound and a derivative of artemisinin; induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM

Artemether – 1 g

Brand:
Cayman
CAS:
71963-77-4
Storage:
-20
UN-No:
Non-Hazardous - /

Artemether is an antiparasitic compound and a derivative of artemisinin (Item No. 11816).{48487} It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively).{48485} Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively.{48486} It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg.{48487} Formulations containing artemether have been used in the treatment of malaria.  

 

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SKU: 11815 - 1 g Category:

Description

An antiparasitic compound and a derivative of artemisinin; induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively); reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice (CD50s = 7.1 and 55 mg/kg, respectively); reduces the worm burden of S. mansoni trematodes in mice at doses ranging from 200-500 mg/kg

Formal name: (3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin

Synonyms:  (+)-Artemether|SM-224

Molecular weight: 298.4

CAS: 71963-77-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Infectious Disease|Parasitic Diseases|Schistosomiasis

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