An antimalarial agent; active against 3D7

Artefenomel – 1 mg

Brand:
Cayman
CAS:
1029939-86-3
Storage:
-20
UN-No:
Non-Hazardous - /

Artefenomel is an ozonide antimalarial agent.{52714} It is active against 3D7, Cam3.II, and Cam3.II_rev P. falciparum strains (LC50s = 8.7, 4.4, and 6.1 nM, respectively). Artefenomel reduces the number of trophozoites in P. falciparum-infected isolated human red blood cells (IC50 = 31 nM).{52715} In vivo, artefenomel (30 mg/kg) is 100% curative in a mouse model of P. berghei infection.{52716}  

 

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SKU: 30677 - 1 mg Category:

Description

An antimalarial agent; active against 3D7, Cam3.II, and Cam3.II_rev P. falciparum strains (LC50s = 8.7, 4.4, and 6.1 nM); reduces the number of trophozoites in P. falciparum-infected isolated human red blood cells (IC50 = 31 nM); 100% curative in a mouse model of P. berghei infection at 30 mg/kg

Formal name: 4-[2-(4-cis-dispiro[cyclohexane-1,3′-[1,2,4]trioxolane-5′,2′′-tricyclo[3.3.1.13,7]decan]-4-ylphenoxy)ethyl]-morpholine

Synonyms:  OZ439

Molecular weight: 469.6

CAS: 1029939-86-3

Purity: ≥98%

Formulation: A solid

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