A covalent inhibitor of K-RASG12C (IC50 = G12C (IC50s = 150 nM) over various cells expressing wild-type K-RAS (IC50s = >10 μM); induces tumor regression in a MIA-PaCa2 mouse xenograft model at 200 mg/kg; decreases tumor volume in K-RASG12C-expressing PDX mouse models

ARS1620 – 1 mg

Brand:
Cayman
CAS:
1698055-85-4
Storage:
-20
UN-No:
Non-Hazardous - /

ARS1620 is a covalent inhibitor of K-RASG12C (IC50 = G12C (IC50s = 150 nM) over H441, A549, and HCT116 cells expressing wild-type K-RAS (IC50s = >10 μM). ARS1620 (200 mg/kg) induces tumor regression in a MIA-PaCa2, but not an H441, mouse xenograft model. It also decreases tumor volume in patient-derived xenograft (PDX) mouse models expressing K-RASG12C, but not K-RASG12D or wild-type K-RAS.  

 

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SKU: 27915 - 1 mg Category:

Description

A covalent inhibitor of K-RASG12C (IC50 = G12C (IC50s = 150 nM) over various cells expressing wild-type K-RAS (IC50s = >10 μM); induces tumor regression in a MIA-PaCa2 mouse xenograft model at 200 mg/kg; decreases tumor volume in K-RASG12C-expressing PDX mouse models

Formal name: 1-[4-[(7S)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one

Synonyms: 

Molecular weight: 430.8

CAS: 1698055-85-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|GTPases||Research Area|Cancer|Cell Signaling|GTPases

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