An inhibitor of NAPE-PLD (IC50 = 33.7 µM); selective for NAPD-PLD over carbonic anhydrase II

ARN19874 – 1 mg

Brand:
Cayman
CAS:
2190502-57-7
Storage:
-20
UN-No:
Non-Hazardous - /

ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD; IC50 = 33.7 µM).{40567} It is selective for NAPD-PLD over carbonic anhydrase II, neutral endopeptidase, and angiotensin-converting enzyme (ACE) up to 50 µM. ARN19874 (50 µM) increases the levels of certain NAPE substrates and decreases the endogenous levels of stearoyl ethanolamide (Item No. 90245), but not oleoyl ethanolamide (Item No. 90265) or palmitoyl ethanolamide (Item No. 90350), in HEK293 cells.  

 

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SKU: 24283 - 1 mg Category:

Description

An inhibitor of NAPE-PLD (IC50 = 33.7 µM); selective for NAPD-PLD over carbonic anhydrase II, neutral endopeptidase, and ACE up to 50 µM; increases the levels of certain NAPE substrates and decreases the endogenous levels of stearoyl ethanolamide, but not oleoyl ethanolamide or palmitoyl ethanolamide in HEK293 cells

Formal name: 1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(4-pyridinyl)phenyl]-6-quinazolinesulfonamide

Synonyms: 

Molecular weight: 394.4

CAS: 2190502-57-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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