A potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme); inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in various melanoma cells; reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 µM

ARN14988 – 10 mg

Brand:
Cayman
CAS:
1502027-70-4
Storage:
-20
UN-No:
Non-Hazardous - /

ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme).{40582} It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide (Item No. 24369) and C16 ceramide (Item No. 10681) in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 µM, respectively).  

 

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SKU: 24284 - 10 mg Category:

Description

A potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme); inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in various melanoma cells; reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 µM, respectively) ,

Formal name: 5-chloro-3-[(hexylamino)carbonyl]-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinecarboxylic acid, 2-methylpropyl ester

Synonyms: 

Molecular weight: 373.8

CAS: 1502027-70-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Cancer||Research Area|Lipid Biochemistry|Sphingolipids

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