An orally bioavailable antagonist of the androgen receptor (IC50 = 16 nM); at 30 mg/kg/d

ARN-509 – 5 mg

Brand:
Cayman
CAS:
956104-40-8
Storage:
-20
UN-No:
Non-Hazardous - /

ARN-509 is an antagonist of the androgen receptor (IC50 = 16 nM).{28061} It binds the receptor but does not cause nuclear localization or DNA binding.{28061} ARN-509 is orally bioavailable and, at 30 mg/kg/d, suppresses tumor growth in a mouse model of castration-resistant prostate cancer.{28061} This compound can be used to study androgen signaling in vitro and in vivo and has potential applications in certain types of cancer.{28062}  

 

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Description

An orally bioavailable antagonist of the androgen receptor (IC50 = 16 nM); at 30 mg/kg/d, suppresses tumor growth in a mouse model of castration-resistant prostate cancer

Formal name: 4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide

Synonyms:  JNJ-56021927

Molecular weight: 477.4

CAS: 956104-40-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens

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