A thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 µM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 µM); does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase

ARM1 – 100 mg

Brand:
Cayman
CAS:
68729-05-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Item No. 20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro.{12673,20329} ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 µM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 µM).{25663} ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.{25663}  

 

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Description

A thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 µM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 µM); does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase

Formal name: 4-[4-(phenylmethyl)phenyl]-2-thiazolamine

Synonyms: 

Molecular weight: 268.4

CAS: 68729-05-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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