An alkaloid with mutagenic activity; forms DNA adducts under anaerobic conditions in vitro at 0.4 mM; oral administration induces bladder

Aristolochic Acid B – 1 mg

Brand:
Cayman
CAS:
475-80-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Aristolochic acid B is an alkaloid that has been found in Aristolochia with mutagenic activity.{45593} It forms DNA adducts under anaerobic conditions in vitro when used at a concentration of 0.4 mM. Oral administration of aristolochic acid B (0.03 mmol/kg) induces bladder, forestomach, and kidney DNA adduct formation in rats. Aristolochic acid B reduces body weight and urine concentrations of sodium, potassium, and calcium, enlarges the liver and kidneys, and increases blood concentrations of hemoglobin and hematocrit in rats.{45594}  

 

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SKU: 28504 - 1 mg Category:

Description

An alkaloid with mutagenic activity; forms DNA adducts under anaerobic conditions in vitro at 0.4 mM; oral administration induces bladder, forestomach, and kidney DNA adduct formation in rats at 0.03 mmol/kg; reduces body weight and urine concentrations of sodium, potassium, and calcium, enlarges the liver and kidneys, and increases blood concentrations of hemoglobin and hematocrit in rats

Formal name: 6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid

Synonyms:  Aristolochic Acid II

Molecular weight: 311.3

CAS: 475-80-9

Purity: ≥98%

Formulation: A crystalline solid

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