A sesquiterpene γ-lactone; inhibits the growth of LS-180

Arglabin – 5 mg

Brand:
Cayman
CAS:
84692-91-1
Storage:
-20
UN-No:
Non-Hazardous - /

Arglabin is a sesquiterpene γ-lactone originally isolated from A. glabella that has anticancer and anti-inflammatory activities.{45407} It inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively).{45408} Arglabin reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 40 µg/g. It is a selective inhibitor of the NLRP3 inflammasome over the NLRP1, AIM2, and NLRC4 inflammasomes when used at a concentration of 50 nM.{45407} Arglabin (50 nM) reduces increases in protein levels of NLRP3, caspase-1, IL-1β, and IL-18 induced by cholesterol crystals in LPS-primed mouse peritoneal macrophages. It decreases plasma levels of IL-1β, oxidized LDL autoantibodies, total cholesterol, and triglycerides, and reduces the size of atherosclerotic lesions in the aorta of mice fed a high-fat diet when administered at a dose of 2.5 ng/g.  

 

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Description

A sesquiterpene γ-lactone; inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively); reduces tumor growth in an SCC-4 mouse xenograft model at 40 µg/g; reduces protein levels of NLRP3, caspase-1, IL-1β, and IL-18 induced by cholesterol crystals in LPS-primed mouse peritoneal macrophages at 50 nM; a selective inhibitor of the NLRP3 inflammasome over the NLRP1, AIM2, and NLRC4 inflammasomes when used at 50 nM; decreases plasma levels of IL-1β, oxidized LDL autoantibodies, total cholesterol, and triglycerides, and reduces the size of atherosclerotic lesions in the aorta of mice fed a high-fat diet at 2.5 ng/g

Formal name: (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one

Synonyms: 

Molecular weight: 246.3

CAS: 84692-91-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation|Innate Immunity

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